Controlled and sustained released formulations are widely used in modern era for the delivery of various ingredients. Oral sustained release product provides an advantage over conventional dosage form by optimizing biopharmaceutics, pharmacokinetic and pharmacodynamic properties of drug. The Sustained release formulation avoids frequents administration of the medicaments while maintaining a uniform and constants release rate of the active pharmaceutical ingredients over long period of time. Sustained release is a drug product formulation that provides the required dosage initially and then maintains or repeats it at desired intervals. Developing oral sustained release matrix tablets for drugs with constant release rate has always been a challenge to the pharmaceutical technologist. All pharmaceutical dosage forms contain many additives besides the active ingredients to assist manufacturing and to obtain the desired effect polymers have been successfully employed in the formulations to sustain the release of drug. Both the natural and synthetic polymers are employed in this process. Drug release through matrix system is determined by water penetration, polymer swelling, drug dissolution, drug diffusion and matrix erosion. Highly water soluble drugs are formulated as sustained release drug delivery system.
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